Immunological influences in attention-deficit disorder and schizophrenia: Is there a link between these two conditions?
Identifieur interne : 000446 ( Main/Exploration ); précédent : 000445; suivant : 000447Immunological influences in attention-deficit disorder and schizophrenia: Is there a link between these two conditions?
Auteurs : R. J. Holden ; I. S. Pakula [Australie]Source :
- Medical Hypotheses [ 0306-9877 ] ; 1995.
Abstract
This paper aims to explore the influence of the immune system on the pathobiochemistry of movement disorders (Tourette syndrome, obsessive compulsive disorders and attention-deficit disorder, with and without hyperactivity) and schizophrenia. In children, a temporal relationship has been observed between contraction of a group A β-hemolytic streptococcal infection and subsequent presentation with one of the movement disorders. Pathology investigations reveal that elevated antineuronal antibodies are associated with movement disorders. Similarly, elevations in interleukin-1β and interleukin-6 have been reported in schizophrenia. It is now known that the immune system can be activated by conditions other than a viral or bacterial infection, such as: neurological insult, neurotoxicity - endogenous and environmental, neurotransmitter and cholesterol dysregulation. These latter avenues of immune system activation will be explored with respect to schizophrenia.
Url:
DOI: 10.1016/0306-9877(95)90242-2
Affiliations:
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